Role of circular RNAs in visceral organ fibrosis.

Abstract Circular RNAs (circRNAs) are a novel class of noncoding RNAs produced during pre-mRNA splicing and are emerging as new members of the gene regulatory network. Unlike linear RNAs, circRNAs have a unique structure with a covalently closed loop formed from the ligation of exons, introns, or both. CircRNAs are widely expressed in various organisms in a species-, tissue-, developmental stage- and disease-specific manner; circRNAs have been demonstrated to play a vital role in the pathogenesis and progression of human diseases. Fibrosis is characterized by an abnormal excessive deposition of extracellular matrix (ECM) in the extracellular space and plays important roles in many different pathologies of various organs. CircRNAs function as master regulators of gene expression to “sponge” or sequester other genes and target gene expression, transcription, splicing, etc. Increasing evidence has revealed that circRNAs are tightly associated with fibrotic diseases in various organs, including the lungs, liver, heart and kidneys. Herein, we provide the current understanding of the molecular characteristics of circRNAs and summarize the findings from circRNA studies in which the functions and mechanisms of action of circRNAs in organ fibrosis were proposed.