α-Alkoxycarbonyl-α-hydroxy secondary amides from a carbamoylsilane and α-ketoesters
2017
Abstract The addition of N -methoxymethyl- N -organylcarbamoyl(trimethyl)silane to α -ketoesters in anhydrous toluene at 60 °C afforded α -alkoxycarbonyl - α - siloxy amides in high yields (75–96%). The methoxymethyl was used as an amino protecting group and could be easily converted into hydrogen atom by simple acid hydrolysis leading to α -alkoxycarbonyl - α - hydroxy secondary amides.
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