Iodobenzene diacetate-mediated hetero-domino transformations

Abstract Treatment of a series of unsaturated diols with iodobenzene diacetate (PhI(OAc) 2 ), in various solvents gave cyclic ene-acetals by a sequential oxidative cleavage-intramolecular [4+2] cycloaddition. The reaction is easy to perform, can be scaled up safely and occurs efficiently irrespective of the diol stereochemistry.