A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses

2014 
Deubiquitinases (DUBs) are peptidases that remove ubiquitin from post-translationally modified proteins. The identification of a selective small-molecule inhibitor of the USP1–UAF1 deubiquitination complex reveals a role for deubiquitination in regulating the DNA damage response.
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