Direct Site-Specific Radiolabeling of an Affibody Protein with 4-[18F]Fluorobenzaldehyde via Oxime Chemistry

Mohammad Namavari,Omayra Padilla De Jesus,Zhen Cheng,Abhijit De,Ernest William Kovacs,Jelena Levi,Rong Zhang,Joshua K. Hoerner,Hans Grade,Faisal Ahmed Syud,Sanjiv S. Gambhir

Direct Site-Specific Radiolabeling of an Affibody Protein with 4-[18F]Fluorobenzaldehyde via Oxime Chemistry

2008

Mohammad Namavari
Omayra Padilla De Jesus
Zhen Cheng
Abhijit De
Ernest William Kovacs
Jelena Levi
Rong Zhang
Joshua K. Hoerner
Hans Grade
Faisal Ahmed Syud
Sanjiv S. Gambhir

Purpose In this study, we introduce a methodology for preparing 18F-labeled Affibody protein, specifically 18F-Anti-HER2 dimeric Affibody (14 kDa), for in vivo imaging of HER2neu with positron emission tomography (PET).

Keywords:

Nuclear medicine
Positron emission tomography
Direct site
Preclinical imaging
Oxime
Chemistry

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