In Vivo Lung Deposition of Hollow Porous Particles from a Pressurized Metered Dose Inhaler
2002
Purpose: PulmoSphere™ particles are specifically engineered for delivery by the pulmonary route with a hollow and porous morphology, physical diameters < 5 μm, and low tap densities (circa 0.1 g.cm-3). Deposition of PulmoSphere particles in the human respiratory tract delivered by pressurized metered dose inhaler (pMDI) was compared with deposition of a conventional micronized drug pMDI formulation.
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