Zinc (II) porphyrins as viable scaffolds to stabilize hydrogen sulfide binding at the metal center

Abstract H 2 S is an important biological messenger but its reactivity and physiological concentrations are largely controversial. On the other hand, reactivity of H 2 S with biologically relevant metal scaffolds for the selective tracking of H 2 S in biological fluids is underexplored. In this work we investigated interaction of monohydrogensulfide with a series of zinc porphyrins by 1 H NMR, UV–vis and ESI mass experiments. The results provide evidence that HS − binds the metal center for all the investigated complexes.