Novel α -sulfamidophosphonate analogues of fotemustine: efficient synthesis using ultrasound under solvent-free conditions

The development of new clean and effective processes for the preparation of new elaborated compounds is currently an important research axis in organic chemistry, thus in recent years, the application of ultrasound has gained a very important development in synthetic organic chemistry. In this context, we have developed a new access route to sulfamidophosphonate analogues of fotemustine which is known to be a cytotoxic alkylating agent, using ultrasonic irradiation as a source of activation of this type of reaction, starting from sulfonamide, triethylphosphite, and various aldehydes via three component reaction. A wide range of substrates is compatible in this reaction, producing good yields (70–85%) in short time (30–60 min). All products were carefully characterized by 1H, 13C NMR as well as IR and HRMS.