Indole, azaindole and heterocyclic amides of 4-alkenyl piperidine

2003 
A compound of Formula I, including pharmaceutically acceptable salts thereof, ** ** Formula wherein: Z is Q is selected from the group consisting of: -W- is R1, R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, cyano, nitro, COOR 8, XR 9 and B; m is 2; R6 is O or does not exist; R7 is (CH2) nR10; n is 0-6; R10 is selected from the group consisting of H, (1-6C) alkyl, -C (O) -C (C1-6), C (O) -phenyl and CONR11R12; R11 and R12 are each independently H, alkyl (1-6C) or phenyl; - - represents a carbon-carbon bond or does not exist; D is selected from the group consisting of hydrogen, (1-6C) alkyl, (C2-6) alkynyl, (3-6C) cycloalkyl, halogen, cyano, -CONR32R33, -SO2R32, COR32, COOR 8, tetrahydrofuryl, pyrrolidinyl, phenyl and heteroaryl; wherein said alkyl (C1-6), (C2-6) alkynyl, phenyl and heteroaryl are each independently optionally substituted with one to three same or different members selected from the group G; heteroaryl is selected from the group consisting of furanyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, pyrazolyl, tetrazolyl, triazolyl, pyridinyl, pyrazinyl, pyridazinyl and pyrimidinyl;
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