Synthesis of macrocycles and their application as chiral solvating agents in the enantiomeric recognition of carboxylic acids and α-amino acid derivatives

Abstract The chiral macrocycles 1 and 2 with multiple binding sites have been synthesized from D -phenylalanine as chiral solvating agents (CSAs) for the enantiomeric discrimination and determination of the enantiomeric excess of carboxylic acids and a-amino acids derivatives by the 1 H NMR spectroscopy. The results show that chiral macrocycles 1 and 2 are effective CSAs towards the carboxylic acids and a-amino acids derivatives.