Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans

Mohini Ranganathan,Joao P. De Aquino,Jose Cortes-Briones,Rajiv Radhakrishnan,Brian Pittman,Savita G. Bhakta,Deepak Cyril D'Souza

Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans

2019

Mohini Ranganathan
Joao P. De Aquino
Jose Cortes-Briones
Rajiv Radhakrishnan
Brian Pittman
Savita G. Bhakta
Deepak Cyril D'Souza

Rationale The catechol-O-methyl transferase (COMT) enzyme has been implicated in determining dopaminergic tone and the effects of delta-9-tetrahydrocannabinol (THC) in the human brain.

Keywords:

Methyltransferase
Dopamine
Internal medicine
Psychology
Genetic variability
Endocrinology
Cannabinoid
Delta-9-tetrahydrocannabinol
Catechol
Tolcapone
Placebo
rs4680
Psychotomimetic
Dopaminergic

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