DNA methyctransferase 1 and gynecological malignancies

DNMT1,the main member of the DNA methyltransferase (DNMT) family,plays a core role in maintaining and regulating tumor cell genome-wide and the local area methylation.DNMT1 is highly expressed in gynecological malignancies,which leads to abnormal DNA methylation of genes,especially high methylation of tumor suppressor genes,gene expression silencing,and malignant cell growth. Key words: Site-specific DNA methyltransferase (cytosine-specific);  Genital neoplasms,female