Kinetically controlled acylation of 6-APA catalyzed by penicillin acylase from Streptomyces lavendulae: effect of reaction conditions in the enzymatic synthesis of penicillin V

Daniel Hormigo,María Teresa López-Conejo,Lara Serrano-Aguirre,Alberto García-Martín,Ana Saborido,Isabel de la Mata,Miguel Arroyo

Kinetically controlled acylation of 6-APA catalyzed by penicillin acylase from Streptomyces lavendulae: effect of reaction conditions in the enzymatic synthesis of penicillin V

2019

Daniel Hormigo
María Teresa López-Conejo
Lara Serrano-Aguirre
Alberto García-Martín
Ana Saborido
Isabel de la Mata
Miguel Arroyo

Enzymatic synthesis of penicillin V (penV) by acylation of 6-aminopenicillanic acid (6-APA) was carried out using methyl phenoxyacetate (MPOA) as activated acyl donor and soluble penicillin...

Keywords:

Organic chemistry
Catalysis
Enzyme
Chemistry
Penicillin
Streptomyces lavendulae
Penicillin Acylase
Acylation
6-APA
enzymatic synthesis
reaction conditions

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