Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands.

Abstract A series of non-imidazole histamine H 3 receptor antagonists based on the (3-phenoxypropyl)amine motif, which is a common pharmacophore for H 3 antagonists, has been identified. A preliminary SAR study around the amine moiety has identified 8a as a potent H 3 antagonist possessing a good pharmacokinetic profile in the rat.