VARIATIONS OF THE BETA-GLYCURONIDASIC ACTIVITY IN ORGANS OF THE WHOLE-BODY IRRADIATED GUINEA PIG

A study was made of the behavior of the helial phagocyt -glycuronidasic activity (according to Huggins, Talalay, and Tischmann's method) after 2 and 5 hr and 1, 3, and 8 days following panroentgenirradiation on homogenized brain, liver, spleen, adrenals, kidney, testicle, ovary, and plasma of 65 fullgrown guinea pigs. The study of the data obtained shows that panroentgenirradiation (at a dosage of 250 to 500 r) considerably modifies the enzymatic activity both of the blood and the organs. Both in the blood and in the organs it could be established that there exists an increase of the helial phagocyt glycuronidasic activity directly proportional to the intensity of the damage due to ionizing radiations, which is folloiwed by a decrease 8 days after irradiation. The phenomenon is discussed, and different theories are advanced for its interpretation. (auth)