Novel One-Pot Synthesis and Antimicrobial Activity of 2-Amino-4H-1,3-Oxazines and 2-Amino-4H-1,3-Thiazines

An efficient synthesis of 1,3-oxazine and 1,3-thiazine derivatives has been demonstrated through a one-pot multicomponent condensation reaction (MCR). Urea and thiourea have been used as reagent and catalyst system for this reaction. The method produced good to excellent product yields. The synthesized compounds were evaluated for their antibacterial and antifungal activities in vitro against four bacteria and two fungi.