Serotonin-1A receptor alterations in depression: a meta-analysis of molecular imaging studies

Postmortem studies of people who have successfully committed suicide and people with depression have implicated the serotonin-1A (5-HT 1A ) receptor system in the pathophysiology of depression. Several molecular imaging studies have investigated alterations in 5-HT 1A receptors in patients with depression using positron emission tomography and have reported conflicting results.