N-(Pyrimidin-4-yl) and N-(Pyridin-2-yl) phenylalanine derivatives as VLA-4 integrin antagonists

John Robert Porter,Sarah Catherine Archibald,Julien Alistair Brown,Kirstie Childs,David Critchley,John Clifford Head,Brian Hutchinson,Ted A.H. Parton,Martyn K. Robinson,Anthony Shock,Graham John Warrellow,Alex Zomaya

N-(Pyrimidin-4-yl) and N-(Pyridin-2-yl) phenylalanine derivatives as VLA-4 integrin antagonists

2002

John Robert Porter
Sarah Catherine Archibald
Julien Alistair Brown
Kirstie Childs
David Critchley
John Clifford Head
Brian Hutchinson
Ted A.H. Parton
Martyn K. Robinson
Anthony Shock
Graham John Warrellow
Alex Zomaya

The SAR studies to optimise both potency and rate of clearance in the rat for a series of pyrimidine and pyridine based VLA-4 antagonists are described.

Keywords:

Pyrimidine
Biochemistry
Pyridine
Organic chemistry
Potency
Phenylalanine
VLA-4
Stereochemistry
Integrin
Carboxamide
Chemistry
In vivo
In vitro
Chemical synthesis

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