Catalyst‐Free Halogenation of α‐Diazocarbonyl Compounds with N‐Halosuccinimides: Synthesis of 3‐Halooxindoles or Vinyl Halides.
2016
A novel catalyst-free halogenative cyclization of N-aryl diazoamides with N-halosuccinimides (NXS) is reported for the synthesis of 3-halooxindoles through a carbene-free mechanism. N-Aryl diazoamides reacted with NXS under mild and catalyst-free conditions to afford the corresponding 3-halooxindoles in good yields. This transformation is proposed to proceed through diazonium ion formation followed by intramolecular Friedel–Crafts alkylation.
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