EI-1941-1 and-2, Novel Interleukin-1β Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941

EI-1941-1 and -2 isolated from the culture broths of Farrowia sp. selectively inhibited the human recombinant ICE activity with IC50 values of 0.086 and 0.006μM, respectively, without inhibiting elastase and cathepsin B. EI-1941-1 and -2 also inhibited mature interleukin-1β secretion from THP-1 cells induced by LPS with IC50 values of 5.0 and 10.3μM, respectively. Biochemical characterizations of EI-1941-1 and-2 are described in this article.