Efficacy evaluation of three modified-live PRRS vaccines against a local strain of highly pathogenic porcine reproductive and respiratory syndrome virus

Abstract Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) is characterized by high fever and high mortality in pigs of all ages and has severely affected the pork industry of China in the last decades. This study evaluated the differences in protection conferred by of three MLV PRRS vaccines derived from classical PRRSV (C-PRRSV, VR2332) and HP-PRRSV (TJM-F92 and JXA1-R) against the field challenge of HP-PRRSV TP strain (JXA1-R like). Compared to the experiment pigs in control group which were vaccinated with normal saline, the MLV PRRS vaccinated pigs had milder clinical symptoms, fewer pathological changes in the lung, and higher body weight gain at the end of the study. However, piglets vaccinated with VR2332 had higher body temperature, higher viral loads and lower body weight gain when compared with piglets vaccinated with TJM-F92 or JXA1-R vaccines at the end of the study. The results demonstrated that VR2332 vaccine provided a limited cross-protection against the HP-PRRSV TP strain infection, while in contrast the TJM-F92 and JXA1-R vaccines provided more efficacious protection. The findings of this study could serve as a valuable reference guide for the pig producers and veterinarians when considering the choice of which type of MLV PRRS vaccines to protect their pig herds against field challenge by HP-PRRSV TP strain.