Synthesis and characterization of a series of achiral and chiral mono- and bis[(dien)Pt(II)I]I derivatives as potential DNA and RNA structure probes and anticancer drugs

This paper reports the design, synthesis, and characterization of a series of achirally and chirally substituted diethylenetriamine (dien) and bis(dien) complexes of Pt(II) for study as potential nucleic acid structure and conformation probes. Chiral diisopropyl and achiral tetramethyl derivatives of [(dien)Pt(II)I]I, complexes R- and S-1b-d, were designed to discriminate between B and Z conformations of DNA.