Highly Enantioselective Hydrogenation of ο-Alkoxy Tetrasubstituted Enamides Catalyzed by a Rh/(R,S)-JosiPhos Catalyst
2015
Rh/(R,S)-JosiPhos complex-catalyzed asymmetric hydrogenation of o-alkoxy tetrasubstituted enamides has been achieved, and it furnished a set of β-amino alcohol analogues in high yields and excellent enantiomeric excesses (>99% conversion, up to 99% ee).This method provides valuable chiral building blocks in chiral pharmaceuticals and useful motifs for catalysts.
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