Lysine Sulfonamides as Novel HIV-Protease Inhibitors: Nε-Acyl Aromatic α-Amino Acids.
2006
A series of lysine sulfonamide analogues bearing Nepsilon-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses.
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