THE SPECIFICITY OF THE CHROMOSOMAL ABNORMALITIES IN HUMAN COLONIC POLYPS:: A Cytogenetic Study of Multiple Polyps in a Case of Gardner's Syndrome

The chromosomes were studied in 7 polyps of the large bowel in a case of Gardner's syndrome. All tumours were histologically non-invasive. Four polyps had a normal diploid stemline and showed a predominantly hyperdiploid chromosome variation. Three polyps had heteroploid stemlines: two were pseudodiploid and one was hyperdiploid. The chromosomal difference between polyps of different size was merely quantitative. The same non-random karyotypic pattern was found in all polyps irrespective of size and histological grading.