Insight into the Loading and Release Properties ofan Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrierfor Oxaliplatin Drug: Cytotoxicity and Release Kinetics
2020
Kaolinite layers were exfoliated
as single sheets and admixed
with cellulose fibers, forming an advanced exfoliated kaolinite/cellulose
fiber (EXK/CF) composite, which was characterized as a promising carrier
for the oxaliplatin (OL) drug to induce safety as well as the therapeutic
effect. The EXK/CF composite exhibited promising loading capacity
and achieved an experimental value of 670 mg/g and an expected theoretical
value of 704.4 mg/g. The loading behavior of OL using the EXK/CF composite
followed the pseudo-first-order kinetic model and the Langmuir equilibrium
model, achieving an adsorption energy of 7.7 kJ/mol. This suggested
physisorption and homogeneous loading behavior of the OL molecules
in a monolayer form. The release profile of OL from EXK/CF continued
for about 100 h with maximum release percentages of 86.4 and 95.2%
in the phosphate and acetate buffers, respectively. The determined
diffusion exponent from the Korsmeyer–Peppas kinetic model
suggested non-Fickian transport behavior of the OL molecules and releasing
behavior controlled by erosion as well as diffusion mechanisms. Regarding
the cytotoxic effect, the EXK/CF composite has a high safety impact on the normal
colorectal cells (CCD-18Co) and higher toxic impacts on the colorectal
cancer cell (HCT116) than the free oxaliplatin drug.
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