High pressure liquid chromatographic determination of the new non-steroidal anti-inflammatory agent butibufen.

High performance liquiq chromatography (HPLC) method for the determination and validation of a new non-steroidal anti-inflammatory agent, butibufen (CAS 55837-18-8), microencapsulated butibufen and its pharmaceutical forms-tablets, sachets (microencapsulated butibufen with excipients), microemulsion and cream-is described. Acetonitrile proved to be the best solvent for the extraction of butibufen from its pharmaceutical forms