Grincamycin B functions as a potent inhibitor for glioblastoma stem cell via targeting RHOA and PI3K/AKT.

Yue-Liang Yao,Si Sun,Mianfu Cao,Min Mao,Jiang He,Qu-Jing Gai,Yan Qin,Xiao Xue-yao,Hui Min Lu,Fanglin Chen,Wenying Wang,Min Luo,Hua Zhang,Hongbo Huang,Jianhua Ju,Xiu-wu Bian,Yan Wang

Grincamycin B functions as a potent inhibitor for glioblastoma stem cell via targeting RHOA and PI3K/AKT.

2020

Yue-Liang Yao
Si Sun
Mianfu Cao
Min Mao
Jiang He
Qu-Jing Gai
Yan Qin
Xiao Xue-yao
Hui Min Lu
Fanglin Chen
Wenying Wang
Min Luo
Hua Zhang
Hongbo Huang
Jianhua Ju
Xiu-wu Bian
Yan Wang

Glioblastoma multiforme (GBM) is the most malignant form of glioma and the overall survival time of patients with GBM is usually less than 14 months. Therefore, it is urgent to find new and effecti...

Keywords:

Pharmacology
Chemistry
RHOA
Glioblastoma
Stem cell
Protein kinase B
Glioma
overall survival
Grincamycin
PI3K/AKT/mTOR pathway

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