Occurrence, mass loads, and ecological risks of amphetamine-like substances in a rural area of South China.

The occurrence and levels of amphetamine like substances (ALSs) in various environments, as a group of illicit psychoactive substances, have attracted great attention due to their potential ecological risks. In this study, three ALSs (i.e., ephedrine (EPH), amphetamine (AMP) and methamphetamine (METH)) in the raw domestic wastewater (RDW) and surface river water (SRW) collected from the rural area in South China were analyzed. METH was identified as the prevalent and dominant ALS in the RDW, which was detected in approximately 99.0% of the samples with a mean concentration of 0.7 μg·L-1, followed by AMP and EPH. Consistent trend was also found in the SRW collected from the same region. METH concentrations in the SRW were significantly and positively correlated with those in the RDW (p < 0.05), indicating that the discharge of RDW could be the important source of METH in the nearby rivers. The mean mass load of METH in the study rural area was about 65.8 mg·day-1·1000 inhabitants-1. Source apportionment showed that the abuse consumption was the main source of METH at most of sampling towns in the investigated rural area, and the mean mass load of METH at these towns (24.5 mg·day-1·1000 inhabitants-1) might reflect the abuse level of METH in this region. The disposal and illegal synthesis of METH could be important point sources, which led to the elevated METH level in the RDW. Risk assessment demonstrated that ALSs posed a minimal or medium risk to aquatic organisms. Our results provided valuable insights into the mass loads, source characteristics and ecological risks of ALSs in the rural area.