Solution-phase parallel synthesis of 4,6-diaryl-pyrimidine- 2-ylamines and 2-amino-5,5-disubstituted-3,5-dihydro-imidazol- 4-ones via a rearrangement
2003
The reaction of chalcones and guanidine was investigated in the presence of an oxidizing agent. Depending on the order of the addition either a 4,6-diaryl-pyrimidine-2-ylamine or 2-amino-5,5-disubstituted-3,5-dihydro-imidazol-4-one was obtained. The structures of the imidazolinones were elucidated by NMR spectroscopy and X-ray crystallography and for its formation a mechanism was proposed.
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