Hydrothermal synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial evaluation of the copper (II) ciprofloxacin complex: [Cu(cf)2(BF4)2]·6H2O

Abstract The hydrothermal reaction of ciprofloxacin ( 1 ) with Cu(BF 4 ) 2 ·6H 2 O yields a copper complex having a molecular formula, [Cu(cf) 2 (BF 4 ) 2 ]·6H 2 O (cf = ciprofloxacin), which is characterized by spectroscopic and electrochemical measurements as well as single crystal X-ray studies [ a =9.1079(13), b =9.6112(16), c =11.4542(18) A, α =90.518 (19)°, β =99.160 (18)°, γ =93.315 (19)°, P1bar, Z =1]. The F 2 O 4 donor atom set forms a (4+2) distorted octahedral geometry around the central copper atom; which has a highly facile copper redox couple (+0.23 V). The copper conjugate exhibits a significant enhancement in the antitubercular activity probably arising out of its rapid intracellular reduction leading to oxygen activation, which is detrimental to the mycobacteria.