Investigation of antidiabetic effect of a new dicarboxylic acid coordination polymer with Zn(II)

Abstract In this paper, a zinc(II)-based coordination polymer, Zn2 [(C6H8(COOH)2]2 (1) [(C6H8(COOH)2 ​= ​1,2-cyclopentanedicarboxylic acid, CPDA)], was successfully synthesized by solvothermal method. Thereafter, 1 was characterized by single crystal and powder X-ray diffraction, elemental analysis, thermogravimetric analysis and infrared spectrum techniques. In the hypoglycemic experiment, the results showed that 1 could effectively increase the glucose uptake in insulin resistance (IR)-type HepG2 cells. Besides, 1 displayed favorable antidiabetic activity in contrast to the Zinc nitrate and the CPDA ligand. The mechanism of 1 to alleviate insulin resistance might be related to the reduction of the intracellular reactive oxygen species (ROS) level and the regulation of the ROS/JNK/AKT signaling pathway.