Combinations comprising phentermine and topiramate, and methods for their preparation

The present invention relates to a combination comprising an immediate release pellets and topiramate-release pellets of phentermine, pellets of the topiramate: a) pellet core cavity; wherein b) topiramate, binderless be an active agent layer is disposed on the surface of the pellet cores of the cavity, the active agent layer; c) a release coating layer comprising ethyl cellulose and PVP K30, arranged outside of the active agent layer is the, the release coating layer comprises, providing said combination. The present invention further discloses a process for the preparation of the combination.