Alkylzirconocenes in Organic Synthesis: An Overview

Organozirconium chemistry has found extensive applications in organic synthesis since its discovery in the last century. Alkyl­zirconocenes, which are easily generated by the hydrozirconation of alkenes with the Schwartz reagent, are widely utilized for carbon–carbon­ and carbon–heteroatom bond formation. This short review summarizes the progress to date on the applications alkylzirconocenes in organic synthesis. 1 Introduction 2 General Methods for Generating Alkylzirconocenes 3 Transformations of Alkylzirconocenes by Heteroatoms 4 Insertion of Unsaturated Groups into Alkylzirconocenes 5 Transmetalations 6 Cross-Coupling Reactions of Alkylzirconocenes 7 Photochemistry of Alkylzirconocenes 8 Bimetallic Reagents of Zirconium 9 Asymmetric Transformations 10 Applications of Alkylzirconocenes Generated from the Negishi Reagent 11 Conclusions and Outlook