Poteinicos acylated aggregates and their use in order to increase the signal in an immunoassay for the detection of antibodies.

The invention relates to protein aggregate, which is acylated with groups - CO - R, wherein R represents C Sub.1 {} - C {SUB.4 ALKYL}, which may be substituted carboxy, hydroxy, SO {SUB. {3} hoPo SUB.3}} H {SUB.2, SIGNAL TO STRENGTHEN AND TO AVOID nEGATIVE RESULTS INMUNOASAIS FAKE FOR DETERMINING ANTIBODY. The invention further relates to a reagent with a buffer and reagent LINK LINK WITH A PARTNER OF IMMUNE CONTAINING THIS PROTEIN AGGREGATE.