A report on the Gubbio Study thirty-eight years after its inception.

BACKGROUND The Gubbio Population Study ("Gubbio Study") is a prospective epidemiological study carried out on the resident population of the city of Gubbio, Italy. The study's objectives are both of public health nature (the control and awareness of hypertension), and experimental (the role of electrolyte handling at the cellular membrane level and its relation to hypertension). Additional objectives were addressed during the 30+ year activity of the study, in particular the role of kidney dysfunction. METHODS Three active screenings ('Exams') were performed beginning 38 years ago; the first (Exam 1) in 1983-1986 (5376 individuals - response rate 92%) and two follow-up exams, were completed between 1989-92 (Exam 2) and 2001-2007 (Exam 3). Data collected include demographics, personal and family medical history, lifestyle (smoking, alcohol, diet and physical activity), education, type of work, anthropometry, blood pressure, pulse rate, blood biochemistry, urine biochemistry and special investigations on cellular electrolyte handling. Additional measurements were performed in selected sub-groups of participants. Data on hospitalizations, mortality and causes of death were collected after the completion of Exam 1. RESULTS The main results of the study, presented in this paper, identify new variables to consider in screening for cardiovascular risk factors, and show the impact that the focused and coordinated effort of a longitudinal program can have on a free-living population'. CONCLUSIONS The data are of relevance to Public Health and to experimental medicine alike, and vouch to the importance of the control of risk factors at the community level.