Dynamic Intervention: Pathogen Disarmament of Mitochondrial-Based Immune Surveillance

In this issue of Cell Host & Microbe , Suzuki et al. (2014) describe a Vibrio cholerae Type-III-secreted effector that targets mitochondrial dynamics to dampen host innate immune signaling. This suggests that mammalian hosts possess surveillance mechanisms to monitor pathogen-mediated alterations in the integrity of normal cellular processes and organelles.