Synthesis and radioprotective effects of organic salts of 2,2-dimethylthiazolidine and cystamine

Objective: To improve physical and chemical properties of 2,2-dimethylthiazolidine hydrochloride (DMTD) and enhance the anti-radiation effect. Methods: Various organic salts of 2,2-dimethylthiazolidine and cystamine were synthesized. The drug was administered to mice before 9.03 Gy {sup 60}Co gamma-ray whole body irradiation for evaluation of radioprotective effects. Results: Most of these compounds showed significant radioprotective effects. Among them, DMTD tartrate 250 mg/kg given i.p. 1 hour before irradiation increased the survival rate by 40%. Cystamine succinate 250 mg/kg administered i.p. 15 min. before irradiation increased the survival rate by 77.5%. Conclusion: Cystamine succinate showed marked anti-radiation effect. Further investigation is worthwhile.