Discovery and SAR of Natural-Product-Inspired RXR Agonists with Heterodimer Selectivity to PPARδ-RXR.

Ken-ichi Nakashima,Eiji Yamaguchi,Chihaya Noritake,Yukari Mitsugi,Mayuki Goto,Takao Hirai,Naohito Abe,Eiji Sakai,Masayoshi Oyama,Akichika Itoh,Makoto Inoue

Discovery and SAR of Natural-Product-Inspired RXR Agonists with Heterodimer Selectivity to PPARδ-RXR.

2020

Ken-ichi Nakashima
Eiji Yamaguchi
Chihaya Noritake
Yukari Mitsugi
Mayuki Goto
Takao Hirai
Naohito Abe
Eiji Sakai
Masayoshi Oyama
Akichika Itoh
Makoto Inoue

A known natural product, magnaldehyde B, was identified as an agonist of retinoid X receptor (RXR) α. Magnaldehyde B was isolated from Magnolia obovata (Magnoliaceae) and synthesized along with mor...

Keywords:

Magnaldehyde B
Selectivity
Agonist
Biology
Magnoliaceae
Biochemistry
Magnolia obovata
Retinoid X receptor
Natural product

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