Linear PVA–DTPA–Gd conjugate for magnetic resonance imaging

In this study, we report the preparation and characterization of the PVA–DTPA–Gd conjugate as a potential MRI contrast agent (CA). The r1 value and the r2/r1 ratio were about 5.6 mM−1 s−1 and 1.31, respectively. In vitro toxicity studies not only demonstrated that the polymeric system possessed good biocompatibility, but also proved that the conjugate could be an attractive candidate for CA.