High-voltage protection system of power battery and vehicle

The utility model provides a high-voltage protection system of a power battery. The high-voltage protection system of the power battery comprises a vehicle controller, a collision switch, a first relay, a second relay, a power battery management module and a power supply. The power battery management module comprises the power battery, a power battery controller and a third relay set, wherein the power battery is used for providing high-voltage power and the third relay set is connected with the power battery. The power supply, the first relay, the collision switch and the control end of the second relay are connected in series and in sequence to form a first control return circuit. The power supply, the second relay, the control end of the third relay and the power battery controller are connected in series and in sequence to form a second control return circuit. The high-voltage protection system of the power battery is high in reliability and development cost is not increased. The utility model further provides a vehicle which comprises the high-voltage protection system and a high-voltage system connected with the high-voltage protection system.