Cyclization by C(sp3)–H Arylation with a Transient Directing Group for the Diastereoselective Preparation of Indanes

Philip A. Provencher,Katherine L. Bay,John F. Hoskin,K. N. Houk,Jin-Quan Yu,Erik J. Sorensen

Cyclization by C(sp3)–H Arylation with a Transient Directing Group for the Diastereoselective Preparation of Indanes

2021

Philip A. Provencher
Katherine L. Bay
John F. Hoskin
K. N. Houk
Jin-Quan Yu
Erik J. Sorensen

We report Pd(II)-catalyzed cyclative C(sp3)–H arylation of ketones with a transient directing group (TDG). Based on calculations, the oxidative addition step implicates a highly strained trigonal b...

Keywords:

Trigonal crystal system
Medicinal chemistry
Catalysis
Oxidative addition
Chemistry
Palladium
Indane

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