Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling

Weiwei Sheng,Xiaoyang Shi,Yiheng Lin,Jingtong Tang,Chao Jia,Rongxian Cao,Jian Sun,Guosen Wang,Lei Zhou,Ming Dong

Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling

2020

Weiwei Sheng
Xiaoyang Shi
Yiheng Lin
Jingtong Tang
Chao Jia
Rongxian Cao
Jian Sun
Guosen Wang
Lei Zhou
Ming Dong

Background Our previous study showed Musashi2 (MSI2) promoted chemotherapy resistance and pernicious biology of pancreatic cancer (PC) by down-regulating Numb and p53. We further explored the novel molecular mechanism involving its oncogenic role in PC development.

Keywords:

Cancer research
Musashi2
Pancreatic cancer
Biology
MAPK/ERK pathway
Chemotherapy
NUMB
Epidermal growth factor receptor
Epithelial–mesenchymal transition
Apoptosis
Gene silencing
Phosphorylation
cell morphology

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