Co(II)-coordination polymers: magnetic properties and treatment activity on the chronic subdural hematoma via regulating the releasing of inflammatory cytokines

Abstract Two metal–organic coordination polymers based on phosphonate of {Co(D-Hpmpc)(CH3OH)}n (1) and {Co(D-Hpmpc)}n (2) with diversified dimensional characteristics and coordination patterns (in which the D-H3pmpc = (D)-1-(phosphono-methyl)piperidine-3-carboxylic acid) have been generated through the solvothermal reaction between D-H3pmpc and metal salt Co(NO3)2·6H2O. Magnetic investigations have suggested that there is antiferromagnetic coupling between neighboring metal ions in the two compounds. The two compounds were produced and followed by the bio-evaluation for the chronic subdural hematoma treatment. Firstly, before the indicated treatment, the animal model of chronic subdural hematoma was established. Next, the balance between pro-inflammatory cytokines and anti-inflammatory cytokines in the hematoma capsule was determined with ELISA detection kit. The results of the ELISA detection revealed that compound 1 could significantly reduce the content of pro-inflammatory cytokines in hematoma capsule to about 1/3 to 1/4 of the content in model group. And compound 1 obviously increased the levels of anti-inflammatory cytokines to about 4-5-fold over the model group. Besides, the viability of the normal human cells after the compound treatment were nearly 100%, suggesting both compounds 1 and 2 showed no cytotoxicity on the normal human cells, which have excellent clinical application prospect on the chronic subdural hematoma treatment.