In Vitro Investigation of Antibacterial Activity of Novel 3-Acetylcoumarin Schiff Bases and Their Molecular Docking Studies

A new series of Schiff bases, SB1 to SB6 were synthesized from (1) and (2) with different acid hydrazides. The structures of the synthesized compounds were established on the basis of physical and spectral data. They shows a prominent absorption of -(C=N-) in FTIR. Antibacterial activity of these compounds was performed on Gram +ve and Gram –ve bacteria. SB1, SB4, SB5 and SB6 were found active against Gram +ve and Gram –ve bacteria. Molecular docking study of these derivatives in the IsdH protein cavity was also conducted. SB1 and SB4 establish the best binding energy of –10.3 and – 10.5 Kcal/mol. A survey of existing literature revealed that there are no reports describing the synthesis of such hydrazones.