Genotypic characteristics of Mycobacterium tuberculosis strains from the Republic of Tyva

: To determine the genetic heterogenicity of Mycobacterium tuberculosis isolated from patients with tuberculosis from different districts of the Republic of Tyva, 71 M. tuberculosis strains IS6110 according to the polymorphism of restriction fragment lengths were typed; of them 32 strains were spoligotyped. The study could genetically characterize the groups of M. tuberculosis strains circulating among patients with tuberculosis in the Republic of Tyva. There was a predominance of the W family of mycobacteria (60.56%). The spoligotyping permitted identification of M. tuberculosis with the spoligotype Beijing in the Republic of Tyva. The mycobacteria belonging to this spoligotype were prevalent and accounted for 50% of the strains. The high proportion of strains with the unique spoligotype (25%) that have not earlier been encountered in the international database is a specific feature of the Mycobacterium population from the Republic of Tyva.