STUDIES ON SENSITIVITY OF GASTROINTESTINAL TRACT AGAINST RADIOACTIVITY AND PRODUCTION OF EXPERIMENTAL GASTRIC ULCER BY LOCAL IMPLANTATION OF RADIO COLLOID

Colloids of Au/sup 198/, NaI/sup 131/, and Lu/sup 177/ Cl/sub 3/ in small viny l tubes, diluted to provide a wide range of radiation activities, were implanted at various locations along the gastrointestinal tract. The radiosensitivity of the various segments of the gastrointestinal tract was determined in animals sacrificed at various intervals after the implantations were made. The protective effects of cortisone, ACTH, insulin, atrophine, and chloropromazine against lesions induced by implants of colloidal Au/sup 198/ were evaluated. The physiological effects of the 5 compounds are reviewed. The possible relation of the effects of the compounds on control of gastric secretion of HCl and their protective effects against radiation injury to the gastrointestinal tract is considered. (C.H.)