PIN32 A Systematic Literature Review of the Economic Burden of Hospitalized Adults with COVID-19 in Europe and Asia

2021 
Objectives: This systematic literature review highlights the economic burden of hospitalized adults with COVID-19 in Europe and Asia. Methods: We searched MEDLINE, EMBASE, and EconLit from December 1, 2019 to October 26, 2020. Two independent reviewers assessed all abstracts according to the eligibility criteria. Studies with queries were referred to a third reviewer to reach agreement. Studies that met the inclusion criteria after full-text review were extracted and critically appraised. Results: After removing duplicates, 845 citations were identified through database searches. Sixty-three citations were included for full-text screening;seven observational studies were included (three from Asia, four from Europe). Six studies reported baseline characteristics for hospitalized patients, and all studies reported comorbidities. Commonly reported comorbidities included diabetes (range 11.2%-50%) and hypertension (range 16.3%-64%). The proportion of patients requiring ventilation ranged from 2% to 89%. One study reported that all patients needed invasive ventilation, but due to lack of ventilators, only 64.7% received it. Pharmacology therapy use was reported in five studies: one study treated all patients with hydroxychloroquine+azithromycin, another reported propofol and cisatracurium as the most frequently used therapies. Use of antibiotics ranged from 31% to 100%, and antivirals ranged from 40% to 98.6%. Length of hospital stay was reported in five studies and varied greatly, from mean 4.6 days (SD 2.1) to median 16 days (IQR 10-23). One study estimated per-patient costs for COVID-19 patients at $4,552 for mild cases, $11,058 for severe cases, and $16,652 for critically ill cases. Conclusions: Research showed that the economic burden of COVID-19 hospitalized patients in Europe and Asia is high. This literature is growing, as our search strategy found 800 new citations published from October 2020 to January 2021. These results may be useful for future studies seeking to increase the information base on the economic burden of hospitalized COVID-19 patients.
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