Integrating interacting drugs and genetic variations to improve the predictability of warfarin maintenance dose in Chinese patients.

ObjectiveCompared with genetic factors, drug interactions are largely unexplored in pharmacogenetic studies. This study sought to systematically investigate the effects of VKORC1, STX4A, CYP2C9, CYP4F2, CYP3A4, and GGCX gene polymorphisms and interacting drugs on warfarin maintenance dose.MethodsA r