Effectof transporter andDNArepairgenepolymorphismstolung cancer chemotherapy toxicity

Lung cancer is the first leading cause of cancer deaths. Chemotherapy toxicity is one of factors that limited the efficacy of platinum-based chemotherapy in lung cancer patients.Transporters and DNA repairgenes playcritical roles in occurrence of platinum-based chemotherapy toxicity. To investigate the relationships between transporter and DNA repair gene polymorphisms and platinum-based chemothera- py toxicity in lung cancer patients, we selected 60 polymor- phisms in 14 transporters and DNA repair genes. The poly- morphisms were genotyped in 317 lung cancer patients by Sequenom MassARRAY. Logistic regression was performed to estimate the association of toxicity outcome with the polymorphisms by PLINK. Our results showed that polymor- phisms of SLC2A1 (rs3738514, rs4658, rs841844) were sig- nificantly related to overall toxicity. XRCC5 (rs1051685, rs6941) and AQP2 (10875989, rs3759125) polymorphisms were associated with hematologic toxicity. AQP2 polymor- phisms (rs461872, rs7305534) were correlated with gastroin- testinal toxicity. In conclusion, genotypes of these genes may be used to predict the platinum-based chemotherapy toxicity in lung cancer patients.